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Drug Name CI-1040
Trade Name
Synonyms PD184352|PD-184352
Drug Descriptions

CI-1040 (PD184352) binds and inhibits Mek1 and Mek2, which may inhibit the activation of downstream signaling targets and reduce tumor cell proliferation (PMID: 14613031, PMID: 16009947).

DrugClasses MEK inhibitor (Pan) 23 MEK1 Inhibitor 22 MEK2 Inhibitor 20
CAS Registry Number 212631-79-3


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + CI-1040 Afatinib CI-1040 0 0
CI-1040 CI-1040 29 0
CI-1040 + WZ4002 CI-1040 WZ4002 0 0

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