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Drug Name Dacomitinib
Trade Name Vizimpro
Synonyms PF-00299804|PF299804
Drug Descriptions

Vizimpro (dacomitinib) is a second-generation EGFR inhibitor and pan-HER inhibitor that inhibits HER2 and multiple EGFR subtypes including EGFR T790M, resulting in decreased proliferation and increased apoptosis in EGFR-expressing and HER2-expressing tumor cells (PMID: 22761403, PMID: 18606718). Vizimpro (dacomitinib) is FDA approved for use in patients with metastatic non-small cell lung cancer with EGFR exon 19 deletion or L858R mutation as first-line treatment (FDA.gov).

DrugClasses EGFR Inhibitor 2nd gen 3 HER inhibitor (Pan) 5
CAS Registry Number 1110813-31-4
NCIT ID C53398

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Therapy Name Drugs Efficacy Evidence Clinical Trials
BMS-754807 + Dacomitinib BMS-754807 Dacomitinib 0 0
Crizotinib + Dacomitinib Crizotinib Dacomitinib 0 0
Dacomitinib Dacomitinib 0 7
Dacomitinib + Gedatolisib Dacomitinib Gedatolisib 0 1
Dacomitinib + Osimertinib Dacomitinib Osimertinib 0 1
Dacomitinib + PD-0325901 Dacomitinib PD-0325901 0 0
Dacomitinib + Selumetinib Dacomitinib Selumetinib 0 0


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