Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Dacomitinib
Trade Name Vizimpro
Synonyms PF-00299804|PF299804
Drug Descriptions

Vizimpro (dacomitinib) is a second-generation EGFR inhibitor and pan-HER inhibitor that inhibits HER2 and multiple EGFR subtypes including EGFR T790M, resulting in decreased proliferation and increased apoptosis in EGFR-expressing and HER2-expressing tumor cells (PMID: 22761403, PMID: 18606718). Vizimpro (dacomitinib) is FDA approved for use in patients with metastatic non-small cell lung cancer with EGFR exon 19 deletion or L858R mutation as first-line treatment (FDA.gov).

DrugClasses EGFR Inhibitor 2nd gen 5 HER inhibitor (Pan) 6
CAS Registry Number 1110813-31-4
NCIT ID C53398


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Anlotinib + Dacomitinib + Olaparib + Pemetrexed Disodium + Temozolomide Anlotinib Dacomitinib Olaparib Pemetrexed Disodium Temozolomide 0 0
BMS-754807 + Dacomitinib BMS-754807 Dacomitinib 0 0
Crizotinib + Dacomitinib Crizotinib Dacomitinib 0 0
Dacomitinib Dacomitinib 0 7
Dacomitinib + Gedatolisib Dacomitinib Gedatolisib 0 1
Dacomitinib + Osimertinib Dacomitinib Osimertinib 0 1
Dacomitinib + PD-0325901 Dacomitinib PD-0325901 0 0
Dacomitinib + Selumetinib Dacomitinib Selumetinib 0 0

Additional content available in CKB BOOST