Drug Detail


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Drug Name Uprosertib
Trade Name
Synonyms GSK2141795|GSK-2141795|GSK 2141795
Drug Descriptions

Uprosertib (GSK2141795) is an ATP-competitive inhibitor of AKT, which leads to inhibition of PI3K/AKT signaling potentially resulting in inhibition of cell proliferation and anti-tumor growth (PMID: 24978597, PMID: 32062691).

DrugClasses Akt Inhibitor (Pan) 21 AKT Inhibitor (Pan) - ATP competitive 7
CAS Registry Number 1047634-65-0
NCIT ID C84870


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cisplatin + Uprosertib Cisplatin Uprosertib 0 0
Dabrafenib + Trametinib + Uprosertib Dabrafenib Trametinib Uprosertib 0 1
Dabrafenib + Uprosertib Dabrafenib Uprosertib 0 1
Tipifarnib + Uprosertib Tipifarnib Uprosertib 1 0
Trametinib + Uprosertib Trametinib Uprosertib 0 8
Uprosertib Uprosertib 2 0

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