Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name KX2-391
Trade Name
Synonyms KX-01|Tirbanibulin
Drug Descriptions

Tirbanibulin (KX2-391) is a peptidomimetic inhibitor of Src and pretubulin, with additional activity against FLT3, potentially resulting in decreased tumor growth and metastasis (PMID: 22784709, PMID: 31628188, PMID: 34217323).

DrugClasses FLT3 Inhibitor 65 SRC Inhibitor 31
CAS Registry Number 897016-82-9
NCIT ID C74077

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
KX2-391 KX2-391 10 2
KX2-391 + Oxaliplatin KX2-391 Oxaliplatin 2 0
KX2-391 + Paclitaxel KX2-391 Paclitaxel 0 0
KX2-391 + Tamoxifen KX2-391 Tamoxifen 0 0


Additional content available in CKB BOOST