Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Lestaurtinib
Trade Name
Synonyms CEP-701|KT-5555|A-154475|SP924
Drug Descriptions

Lestaurtinib (CEP-701) inhibits JAK2, FLT3 and NTRK1-3, resulting in antiproliferative activity (PMID: 10415871, PMID: 17143529, PMID: 17442779, PMID: 17984313, PMID: 32441887).

DrugClasses CSF1R Inhibitor 27 FLT3 Inhibitor 61 JAK2 Inhibitor - ATP competitive 15 Trk Receptor Inhibitor (Pan) 30
CAS Registry Number 111358-88-4
NCIT ID C48402


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Cisplatin + Lestaurtinib Cisplatin Lestaurtinib 0 0
Lestaurtinib Lestaurtinib 15 0

Additional content available in CKB BOOST