Drug Detail


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Drug Name Duligotuzumab
Trade Name
Synonyms MEHD7945A
Drug Descriptions

Duligotuzumab (MEHD7945A) is a two-in-one antibody that inhibits both ERBB3 (HER3) and EGFR signaling, resulting in greater efficacy than monospecific HER antibodies against multiple tumor models (PMID: 22014573, PMID: 29506988).

DrugClasses EGFR Antibody 51 HER3 (ERBB3) Antibody 23
CAS Registry Number 1312797-14-0
NCIT ID C116628


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Duligotuzumab Afatinib Duligotuzumab 0 0
Cobimetinib + Duligotuzumab Cobimetinib Duligotuzumab 0 1
Duligotuzumab Duligotuzumab 3 2
Duligotuzumab + Radiotherapy Duligotuzumab Radiotherapy 0 0

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