Drug Detail


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Drug Name Onartuzumab
Trade Name
Synonyms MetMAb|RO5490258|OA-5D5
Drug Descriptions

Onartuzumab is a monovalent antibody that binds MET and inhibits MET/HGF signaling, potentially resulting in decreased tumor growth (PMID: 23882082, PMID: 30472556).

DrugClasses MET Antibody 27
CAS Registry Number 1133766-06-9
NCIT ID C82348


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Erlotinib + Onartuzumab + Paclitaxel Carboplatin Erlotinib Onartuzumab Paclitaxel 0 1
Carboplatin + Onartuzumab + Paclitaxel Carboplatin Onartuzumab Paclitaxel 0 1
Cobimetinib + Onartuzumab Cobimetinib Onartuzumab 0 1
Cobimetinib + Onartuzumab + Vemurafenib Cobimetinib Onartuzumab Vemurafenib 0 1
Erlotinib + Onartuzumab Erlotinib Onartuzumab 0 1
Fluorouracil + Leucovorin + Onartuzumab + Oxaliplatin Fluorouracil Leucovorin Onartuzumab Oxaliplatin 0 0
Onartuzumab Onartuzumab 0 2
Onartuzumab + Vemurafenib Onartuzumab Vemurafenib 0 1

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