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Drug Name PD-0325901
Trade Name
Synonyms PD0325901|PD-901
Drug Descriptions

PD-0325901, a derivative of CI-1040, is a pan-MEK inhibitor, which inhibits activation of MAPK/ERK resulting in decreased tumor cell proliferation (PMID: 18952427, PMID: 32147669).

DrugClasses MEK inhibitor (Pan) 22 MEK1 Inhibitor 20 MEK2 Inhibitor 18

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AMG 510 + PD-0325901 AMG 510 PD-0325901 0 0
APS-2-79 + PD-0325901 APS-2-79 PD-0325901 0 0
BI2536 + PD-0325901 BI2536 PD-0325901 1 0
Dacomitinib + PD-0325901 Dacomitinib PD-0325901 0 0
Dactolisib + PD-0325901 Dactolisib PD-0325901 0 0
GDC-0980 + PD-0325901 GDC-0980 PD-0325901 0 0
Gedatolisib + PD-0325901 Gedatolisib PD-0325901 0 0
Palbociclib + PD-0325901 PD-0325901 Palbociclib 2 1
PD-0325901 PD-0325901 16 3
PD-0325901 + PF-04691502 PD-0325901 PF-04691502 1 0
PD-0325901 + Pictilisib PD-0325901 Pictilisib 1 0
PD-0325901 + Sapanisertib PD-0325901 Sapanisertib 0 0
PD-0325901 + Sorafenib PD-0325901 Sorafenib 2 0
PD-0325901 + Sotrastaurin PD-0325901 Sotrastaurin 1 0
PD-0325901 + ZSTK474 PD-0325901 ZSTK474 0 0


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