Drug Detail


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Drug Name PD-0325901
Trade Name
Synonyms PD0325901|PD 0325901|PD-901|Mirdametinib
Drug Descriptions

PD-0325901, a derivative of CI-1040, is a pan-MEK inhibitor, which inhibits activation of MAPK/ERK resulting in decreased tumor cell proliferation (PMID: 18952427, PMID: 32147669).

DrugClasses MEK inhibitor (Pan) 23 MEK1 Inhibitor 25 MEK2 Inhibitor 23
CAS Registry Number 391210-10-9
NCIT ID C52195


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Apitolisib + PD-0325901 Apitolisib PD-0325901 0 0
APS-2-79 + PD-0325901 APS-2-79 PD-0325901 0 0
BGB3245 + PD-0325901 BGB3245 PD-0325901 0 1
BI2536 + PD-0325901 BI2536 PD-0325901 0 0
Dacomitinib + PD-0325901 Dacomitinib PD-0325901 0 0
Dactolisib + PD-0325901 Dactolisib PD-0325901 0 0
Deucravacitinib + PD-0325901 Deucravacitinib PD-0325901 0 0
Fulvestrant + PD-0325901 Fulvestrant PD-0325901 0 0
Gedatolisib + PD-0325901 Gedatolisib PD-0325901 0 0
Lifirafenib + PD-0325901 Lifirafenib PD-0325901 3 1
Palbociclib + PD-0325901 PD-0325901 Palbociclib 4 1
Palbociclib + PD-0325901 + unspecified PD-L1 antibody PD-0325901 Palbociclib unspecified PD-L1 antibody 0 0
PD-0325901 PD-0325901 15 4
PD-0325901 + PF-04691502 PD-0325901 PF-04691502 0 0
PD-0325901 + Pictilisib PD-0325901 Pictilisib 1 0
PD-0325901 + Sapanisertib PD-0325901 Sapanisertib 4 0
PD-0325901 + Sorafenib PD-0325901 Sorafenib 2 0
PD-0325901 + Sotorasib PD-0325901 Sotorasib 0 0
PD-0325901 + Sotrastaurin PD-0325901 Sotrastaurin 0 0
PD-0325901 + ZSTK474 PD-0325901 ZSTK474 0 0

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