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Drug Name Pexidartinib
Trade Name Turalio
Synonyms PLX3397|CML-261
Drug Descriptions

Turalio (pexidartinib) inhibits multiple receptor tyrosine kinases, including KIT, CSF1R, FLT3, and FLT3/ITD, which may inhibit growth in cancer cells (PMID: 22294205, PMID: 25993548, PMID: 25847190). Turalio (pexidartinib) is FDA approved for use in patients with symptomatic tenosynovial giant cell tumor (FDA.gov).

DrugClasses CSF1R Inhibitor 28 FLT3 Inhibitor 69 KIT Inhibitor 57
CAS Registry Number 1029044-16-3
NCIT ID C88303

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Binimetinib + Pexidartinib Binimetinib Pexidartinib 0 1
Paclitaxel + Pexidartinib Paclitaxel Pexidartinib 0 1
Palbociclib + Pexidartinib Palbociclib Pexidartinib 0 0
Pembrolizumab + Pexidartinib Pembrolizumab Pexidartinib 0 1
Pexidartinib Pexidartinib 60 7
Pexidartinib + PLX9486 PLX9486 Pexidartinib 2 1
Pexidartinib + Samuraciclib Pexidartinib Samuraciclib 0 0
Pexidartinib + Sirolimus Pexidartinib Sirolimus 0 1
Pexidartinib + Vemurafenib Pexidartinib Vemurafenib 1 1
Pexidartinib + VIP152 Pexidartinib VIP152 0 0


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