Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Pexidartinib
Trade Name Turalio
Synonyms PLX3397|CML-261
Drug Descriptions

Turalio (pexidartinib) inhibits multiple receptor tyrosine kinases, including KIT, CSF1R, FLT3, and FLT3/ITD, which may inhibit growth in cancer cells (PMID: 22294205, PMID: 25993548, PMID: 25847190). Turalio (pexidartinib) is FDA approved for use in patients with symptomatic tenosynovial giant cell tumor (FDA.gov).

DrugClasses CSF1R Inhibitor 28 FLT3 Inhibitor 69 KIT Inhibitor 57
CAS Registry Number 1029044-16-3
NCIT ID C88303


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Binimetinib + Pexidartinib Binimetinib Pexidartinib 0 1
Paclitaxel + Pexidartinib Paclitaxel Pexidartinib 0 1
Palbociclib + Pexidartinib Palbociclib Pexidartinib 0 0
Pembrolizumab + Pexidartinib Pembrolizumab Pexidartinib 0 1
Pexidartinib Pexidartinib 60 7
Pexidartinib + PLX9486 PLX9486 Pexidartinib 2 1
Pexidartinib + Samuraciclib Pexidartinib Samuraciclib 0 0
Pexidartinib + Sirolimus Pexidartinib Sirolimus 0 1
Pexidartinib + Vemurafenib Pexidartinib Vemurafenib 1 1
Pexidartinib + VIP152 Pexidartinib VIP152 0 0

Additional content available in CKB BOOST