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SF1126 is a prodrug of LY294002, a pan PI3K inhibitor with additional activity against BRD4, which potentially results in reduced tumor immunosuppression and inhibits tumor growth (PMID: 23355037, PMID: 27496136, PMID: 31018997).
|DrugClasses||BRD4 Inhibitor 7 PI3K Inhibitor (Pan) 38|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|SF1126 + Sorafenib||SF1126 Sorafenib||1||0|