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7-hydroxystaurosporine (UCN-01) is a derivative of staurosporine that inhibits CHK1 and PKC, with higher potency toward PKC-alpha, PKC-beta, and PKC-gamma, and also modulates CDK activity through upregulation of CDK inhibitors, potentially resulting in inhibition of tumor growth (PMID: 8022414, PMID: 15831461, PMID: 15150122, PMID: 31942030).
|DrugClasses||CDK Inhibitor (Pan) 4 CHK1 Inhibitor 15 PKC alpha Inhibitor 6 PKC beta Inhibitor 6 PKC Inhibitor (Pan) 11|
|CAS Registry Number||112953-11-4|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|7-hydroxystaurosporine + Sirolimus||7-hydroxystaurosporine Sirolimus||0||0|