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Drug Name 7-hydroxystaurosporine
Trade Name
Synonyms UCN-01|KRX-0601|NSC-638850
Drug Descriptions

7-hydroxystaurosporine (UCN-01) is a derivative of staurosporine that inhibits CHK1 and PKC, with higher potency toward PKC-alpha, PKC-beta, and PKC-gamma, and also modulates CDK activity through upregulation of CDK inhibitors, potentially resulting in inhibition of tumor growth (PMID: 8022414, PMID: 15831461, PMID: 15150122, PMID: 31942030).

DrugClasses CDK Inhibitor (Pan) 4 CHK1 Inhibitor 15 PKC alpha Inhibitor 6 PKC beta Inhibitor 6 PKC Inhibitor (Pan) 11
CAS Registry Number 112953-11-4


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Therapy Name Drugs Efficacy Evidence Clinical Trials
7-hydroxystaurosporine 7-hydroxystaurosporine 0 0
7-hydroxystaurosporine + Sirolimus 7-hydroxystaurosporine Sirolimus 0 0

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