Drug Detail


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Drug Name Tesevatinib
Trade Name
Synonyms KD019|XL647|EXEL 7647|KD 019
Drug Descriptions

Tesevatinib (XL647) is an inhibitor of multiple receptor tyrosine kinases, including ERBB2 (HER2), EGFR, VEGFR2 and VEGFR3, and EphB4, potentially resulting in decreased tumor growth and angiogenesis (PMID: 17575237, PMID: 30030583).

DrugClasses EGFR Inhibitor (Pan) 54 EPHB4 Inhibitor 6 HER2 Inhibitor 33 VEGFR2 Inhibitor 35 VEGFR3 Inhibitor 6
CAS Registry Number 781613-23-8
NCIT ID C62496


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Tesevatinib Tesevatinib 0 2
Tesevatinib + Trastuzumab Tesevatinib Trastuzumab 0 1

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