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Drug Name XL888
Trade Name
Synonyms XL-888
Drug Descriptions

XL888 inhibits HSP90, resulting in degradation of HSP90 client proteins, and potentially leading to decreased tumor growth (PMID: 23538902, PMID: 22877636, PMID: 29674508).

DrugClasses HSP90 Inhibitor 35
CAS Registry Number 1149705-71-4
NCIT ID C79835

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cobimetinib + Vemurafenib + XL888 Cobimetinib Vemurafenib XL888 0 1
Pembrolizumab + XL888 Pembrolizumab XL888 0 1
Vemurafenib + XL888 Vemurafenib XL888 1 1
XL888 XL888 2 0


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