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Drug Name Defactinib
Trade Name
Synonyms VS-6063|PF-04554878
Drug Descriptions

Defactinib (VS-6063) inhibits FAK, resulting in decreased downstream signaling, and potentially leading to reduced tumor cell proliferation and survival (PMID: 31739184).

DrugClasses FAK inhibitor 15
CAS Registry Number 1073154-85-4
NCIT ID C79809


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Defactinib + Paclitaxel Carboplatin Defactinib Paclitaxel 0 0
Cetuximab + Defactinib + RO5126766 Cetuximab Defactinib RO5126766 0 1
Crizotinib + Defactinib Crizotinib Defactinib 0 0
Decitabine and Cedazuridine + Defactinib Decitabine and Cedazuridine Defactinib 0 1
Defactinib Defactinib 0 7
Defactinib + Encorafenib + RO5126766 Defactinib Encorafenib RO5126766 0 1
Defactinib + Gemcitabine + Nab-paclitaxel + RO5126766 Defactinib Gemcitabine Nab-paclitaxel RO5126766 0 1
Defactinib + Gemcitabine + Pembrolizumab Defactinib Gemcitabine Pembrolizumab 0 1
Defactinib + Letrozole + RO5126766 Defactinib Letrozole RO5126766 0 1
Defactinib + Nivolumab + RO5126766 Defactinib Nivolumab RO5126766 0 0
Defactinib + Pembrolizumab Defactinib Pembrolizumab 0 2
Defactinib + RO5126766 Defactinib RO5126766 0 10
Defactinib + RO5126766 + Sotorasib Defactinib RO5126766 Sotorasib 0 1
Defactinib + Trametinib Defactinib Trametinib 0 0
Defactinib + VS-5584 Defactinib VS-5584 0 1

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