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Drug Name Anlotinib
Trade Name
Synonyms AL3818|AL-3818|AL 3818
Drug Descriptions

Anlotinib (AL-3818) inhibits KDR (VEGFR2) and VEGFR3, FGFR1-4, PDGFRA/B, KIT, and RET, which may inhibit angiogenesis and tumor cell growth (PMID: 27716285, PMID: 32547218, PMID: 32724339).

DrugClasses FGFR Inhibitor (Pan) 24 KIT Inhibitor 55 PDGFR Inhibitor (Pan) 28 RET Inhibitor 48 VEGFR2 Inhibitor 36 VEGFR3 Inhibitor 6
CAS Registry Number 1058156-90-3
NCIT ID C138997

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Anlotinib Afatinib Anlotinib 0 0
AK104 + Anlotinib AK104 Anlotinib 1 0
AK105 + Anlotinib AK105 Anlotinib 0 0
Alflutinib + Anlotinib Alflutinib Anlotinib 0 0
Anlotinib Anlotinib 0 2
Anlotinib + Aumolertinib + Temozolomide Anlotinib Aumolertinib Temozolomide 0 0
Anlotinib + Carboplatin + Paclitaxel Anlotinib Carboplatin Paclitaxel 0 1
Anlotinib + CBT-502 Anlotinib CBT-502 0 0
Anlotinib + Cisplatin + Nab-paclitaxel + Sintilimab Anlotinib Cisplatin Nab-paclitaxel Sintilimab 1 0
Anlotinib + Dacomitinib + Olaparib + Pemetrexed Disodium + Temozolomide Anlotinib Dacomitinib Olaparib Pemetrexed Disodium Temozolomide 0 0
Anlotinib + Gefitinib Anlotinib Gefitinib 0 0
Anlotinib + Irinotecan Anlotinib Irinotecan 1 0
Anlotinib + Nivolumab Anlotinib Nivolumab 0 1
Anlotinib + Nivolumab + Pyrotinib Anlotinib Nivolumab Pyrotinib 0 0
Anlotinib + Olaparib Anlotinib Olaparib 0 0
Anlotinib + Sintilimab Anlotinib Sintilimab 3 0
Anlotinib + Temozolomide Anlotinib Temozolomide 0 0
Anlotinib + Toripalimab Anlotinib Toripalimab 0 0


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