Drug Detail


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Drug Name Gedatolisib
Trade Name
Synonyms PKI-587|PF-05212384|PF 05212384
Drug Descriptions

Gedatolisib (PF-05212384) is an ATP-competitive inhibitor that targets phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, and may result in antitumor activity, including inhibition of tumor growth and tumor regression (PMID: 21325073, PMID: 31822716).

DrugClasses mTOR Inhibitor 51 PI3K Inhibitor (Pan) 40
CAS Registry Number 1197160-78-3
NCIT ID C91732


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Camptothecin + Gedatolisib Camptothecin Gedatolisib 0 0
Carboplatin + Gedatolisib + Paclitaxel Carboplatin Gedatolisib Paclitaxel 0 1
Ceritinib + Gedatolisib Ceritinib Gedatolisib 0 0
Cisplatin + Gedatolisib Cisplatin Gedatolisib 0 1
Cofetuzumab pelidotin + Gedatolisib Cofetuzumab pelidotin Gedatolisib 0 1
Crizotinib + Gedatolisib Crizotinib Gedatolisib 0 0
Dacomitinib + Gedatolisib Dacomitinib Gedatolisib 0 1
Darolutamide + Gedatolisib Darolutamide Gedatolisib 0 1
Docetaxel + Gedatolisib Docetaxel Gedatolisib 0 1
Fulvestrant + Gedatolisib Fulvestrant Gedatolisib 0 1
Fulvestrant + Gedatolisib + Palbociclib Fulvestrant Gedatolisib Palbociclib 0 1
Gedatolisib Gedatolisib 13 4
Gedatolisib + Hydroxychloroquine Gedatolisib Hydroxychloroquine 0 1
Gedatolisib + Irinotecan Gedatolisib Irinotecan 0 0
Gedatolisib + Neratinib Gedatolisib Neratinib 0 0
Gedatolisib + Palbociclib Gedatolisib Palbociclib 2 2
Gedatolisib + PD-0325901 Gedatolisib PD-0325901 0 0
Gedatolisib + Talazoparib Gedatolisib Talazoparib 0 1
Gedatolisib + Verapamil Gedatolisib Verapamil 0 0

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