Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Riluzole
Trade Name
Synonyms Rilutek
Drug Descriptions

Rilutek (riluzole) inhibits metabotropic glutamate receptors, which results in decreased signaling through the MAPK pathway and the PI3K/AKT pathway (PMID: 19458050), and also inhibits voltage-gated ion channels and may directly inhibit protein kinase C (PMID: 10964608, PMID: 32304618).

DrugClasses PKC Inhibitor (Pan) 11
CAS Registry Number 1744-22-5
NCIT ID C47704


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin + Riluzole Bevacizumab Fluorouracil Leucovorin Oxaliplatin Riluzole 0 1
Riluzole Riluzole 0 0
Riluzole + Sorafenib Riluzole Sorafenib 0 1

Additional content available in CKB BOOST