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Rilutek (riluzole) inhibits metabotropic glutamate receptors, which results in decreased signaling through the MAPK pathway and the PI3K/AKT pathway (PMID: 19458050), and also inhibits voltage-gated ion channels and may directly inhibit protein kinase C (PMID: 10964608, PMID: 32304618).
|DrugClasses||PKC Inhibitor (Pan) 10|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Riluzole + Sorafenib||Riluzole Sorafenib||0||1|