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Drug Name Riluzole
Trade Name
Synonyms Rilutek
Drug Descriptions

Rilutek (riluzole) inhibits metabotropic glutamate receptors, which results in decreased signaling through the MAPK pathway and the PI3K/AKT pathway (PMID: 19458050), and also inhibits voltage-gated ion channels and may directly inhibit protein kinase C (PMID: 10964608, PMID: 32304618).

DrugClasses PKC Inhibitor (Pan) 11
CAS Registry Number 1744-22-5
NCIT ID C47704


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin + Riluzole Bevacizumab Fluorouracil Leucovorin Oxaliplatin Riluzole 0 1
Riluzole Riluzole 0 0
Riluzole + Sorafenib Riluzole Sorafenib 0 1

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