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Drug Name Futibatinib
Trade Name Lytgobi
Synonyms TAS-120
Drug Descriptions

Lytgobi (futibatinib) is a third-generation pan-FGFR inhibitor, which results in the inhibition of FGFR-mediated signal transduction pathways and tumor cell proliferation (PMID: 31109923). Lytgobi (futibatinib) is FDA approved for use in patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma harboring FGFR2 fusion or rearrangement (FDA.gov).

DrugClasses FGFR Inhibitor (Pan) 26
CAS Registry Number 1448169-71-8
NCIT ID C114283

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Futibatinib Afatinib Futibatinib 0 0
Binimetinib + Futibatinib Binimetinib Futibatinib 0 1
Cisplatin + Fluorouracil + Futibatinib + Pembrolizumab Cisplatin Fluorouracil Futibatinib Pembrolizumab 0 1
Durvalumab + Futibatinib Durvalumab Futibatinib 0 1
Fluorouracil + Futibatinib + Leucovorin + Oxaliplatin + Pembrolizumab Fluorouracil Futibatinib Leucovorin Oxaliplatin Pembrolizumab 0 1
Fulvestrant + Futibatinib Fulvestrant Futibatinib 0 1
Futibatinib Futibatinib 132 9
Futibatinib + Gefitinib Futibatinib Gefitinib 0 0
Futibatinib + Ibrutinib Futibatinib Ibrutinib 0 0
Futibatinib + Lapatinib Futibatinib Lapatinib 0 0
Futibatinib + Osimertinib Futibatinib Osimertinib 0 0
Futibatinib + Pelitinib Futibatinib Pelitinib 0 0
Futibatinib + Pembrolizumab Futibatinib Pembrolizumab 0 3
Futibatinib + TAS-117 Futibatinib TAS-117 0 0
Futibatinib + TAS0612 Futibatinib TAS0612 0 0
Futibatinib + Trametinib Futibatinib Trametinib 0 0
Futibatinib + Vandetanib Futibatinib Vandetanib 0 0


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