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Drug Name MM-141
Trade Name
Synonyms Istiratumab
Drug Descriptions

Istiratumab (MM-141) is a monoclonal antibody, which binds to human epidermal growth factor receptor B3 (ERBB3) and the human insulin-like growth factor-1 receptor (IGF-1R), blocking ligand binding and preventing activation of PI3K/AKT signaling (PMID: 31912800).

DrugClasses HER3 (ERBB3) Antibody 14 IGF1R Antibody 8

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Everolimus + MM-141 Everolimus MM-141 0 1
Gemcitabine + MM-141 + Nab-paclitaxel Gemcitabine MM-141 Nab-paclitaxel 0 1
MM-141 MM-141 0 2


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