Drug Detail


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Drug Name MRK-003
Trade Name
Drug Descriptions

MRK-003 is a gamma-secretase inhibitor which inhibits Notch3 signaling and induces apoptosis in cancer cells (PMID: 17804716, PMID: 23887890).

DrugClasses Gamma secretase inhibitor 13
CAS Registry Number 623165-93-5


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Therapy Name Drugs Efficacy Evidence Clinical Trials
JQ1 + MRK-003 JQ1 MRK-003 0 0
MRK-003 MRK-003 6 0
MRK-003 + Paclitaxel MRK-003 Paclitaxel 0 0
MRK-003 + Radiotherapy MRK-003 Radiotherapy 0 0
MRK-003 + SCH772984 MRK-003 SCH772984 0 0

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