Drug Detail


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Drug Name AZ628
Trade Name
Synonyms AZD628|AZD-628
Drug Descriptions

AZ628 is an irreversible pan-RAF inhibitor with activity against RAF1 and BRAF, including BRAF V600E, which leads to increased cell-cycle arrest and apoptosis of tumor cells (PMID: 18020980, PMID: 23288408).

DrugClasses RAF Inhibitor (Pan) 28
CAS Registry Number 878739-06-1


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Therapy Name Drugs Efficacy Evidence Clinical Trials
AZ628 AZ628 9 0
AZ628 + CPI-455 AZ628 CPI-455 0 0
AZ628 + Selumetinib AZ628 Selumetinib 1 0
AZ628 + Trametinib AZ628 Trametinib 0 0
AZ628 + VX-11e AZ628 VX-11e 0 0

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