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Drug Name Sapanisertib
Trade Name
Synonyms INK128|sapanisertib|TAK-228|MLN0128
Drug Descriptions

Sapanisertib (MLN0128) is an ATP-competitive mTOR kinase inhibitor that induces apoptosis and inhibits growth in tumor cells (PMID: 25519700).

DrugClasses mTOR Inhibitor 51

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABT-737 + Sapanisertib ABT-737 Sapanisertib 0 0
Aflibercept + Sapanisertib Aflibercept Sapanisertib 0 1
Alisertib + Sapanisertib Alisertib Sapanisertib 2 2
AZD4547 + Sapanisertib AZD4547 Sapanisertib 2 0
Bevacizumab + Sapanisertib Bevacizumab Sapanisertib 0 1
Carboplatin + Paclitaxel + Sapanisertib Carboplatin Paclitaxel Sapanisertib 0 1
EHop-016 + Sapanisertib EHop-016 Sapanisertib 1 0
Erdafitinib + Sapanisertib Erdafitinib Sapanisertib 2 0
Exemestane + Sapanisertib Exemestane Sapanisertib 0 1
Fulvestrant + Sapanisertib Fulvestrant Sapanisertib 0 2
Ibrutinib + Sapanisertib Ibrutinib Sapanisertib 0 0
Infigratinib + Sapanisertib Infigratinib Sapanisertib 2 0
Linsitinib + Sapanisertib Linsitinib Sapanisertib 0 0
Linsitinib + Sapanisertib + Trametinib Linsitinib Sapanisertib Trametinib 0 0
Metformin + Sapanisertib Metformin Sapanisertib 0 1
MLN1117 + Paclitaxel + Sapanisertib MLN1117 Paclitaxel Sapanisertib 0 1
MLN1117 + Sapanisertib MLN1117 Sapanisertib 1 4
MLN2480 + Sapanisertib MLN2480 Sapanisertib 0 1
Osimertinib + Sapanisertib Osimertinib Sapanisertib 0 2
PD-0325901 + Sapanisertib PD-0325901 Sapanisertib 0 0
Phenformin + Sapanisertib Phenformin Sapanisertib 0 0
Ponatinib + Sapanisertib Ponatinib Sapanisertib 2 0
Sapanisertib Sapanisertib 7 19
Sapanisertib + SBI-0206965 SBI-0206965 Sapanisertib 1 0
Sapanisertib + Sirolimus Sapanisertib Sirolimus 0 0
Sapanisertib + Tamoxifen Sapanisertib Tamoxifen 0 1
Sapanisertib + Tipifarnib Sapanisertib Tipifarnib 1 0
Sapanisertib + Trametinib Sapanisertib Trametinib 0 0
Sapanisertib + WEHI-539 Sapanisertib WEHI-539 1 0


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