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DNIB0600A (lifastuzumab vedotin) is an antibody-drug conjugate targeting SLC34A2 and is conjugated to monomethyl auristatin E, which leads to disruption of the microtubule network in SLC34A2-expressing cancer cells, thereby potentially inhibiting cell proliferation (PMID: 29401246).
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Bevacizumab + Carboplatin + DNIB0600A||Bevacizumab Carboplatin DNIB0600A||0||1|
|Carboplatin + DNIB0600A||Carboplatin DNIB0600A||0||1|