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Fostamatinib (R788) binds and inhibits Syk kinase thus interfering with mast cell, macrophage, and B-cell activation as well as downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis (NCI Drug Dictionary).
|DrugClasses||SYK Inhibitor 13|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Fostamatinib + Paclitaxel||Fostamatinib Paclitaxel||0||1|
|Fostamatinib + Silmitasertib||Fostamatinib Silmitasertib||1||0|