Drug Detail


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Drug Name PF-00477736
Trade Name
Synonyms PF-477736
Drug Descriptions

PF-00477736 is an ATP-competitive inhibitor of Chk1, which potentially increases sensitivity to chemotherapeutic agents, resulting in decreased tumor growth (PMID: 18723486).

DrugClasses CHK1 Inhibitor 15
CAS Registry Number 952021-60-2
NCIT ID C68820


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adavosertib + PF-00477736 Adavosertib PF-00477736 1 0
Gemcitabine + PF-00477736 Gemcitabine PF-00477736 0 0
PF-00477736 PF-00477736 0 0
PF-00477736 + PF3644022 PF-00477736 PF3644022 6 0

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