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Drug Name RO5520985
Trade Name
Synonyms Vanucizumab|Ang-2-VEGF-A CrossMab|RG-7221|RO-5520985
Drug Descriptions

Vanucizumab (RO5520985) is a bispecific human antibody that binds to both Angiopoeitin-2 and VEGF-A, inhibiting tumor angiogenesis and metastasis in xenograft models (PMID: 24097868, PMID: 29217526, PMID: 32162804).

CAS Registry Number 1448221-05-3
NCIT ID C118578


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Fluorouracil + Leucovorin + Oxaliplatin + RO5520985 Fluorouracil Leucovorin Oxaliplatin RO5520985 0 0
Fluorouracil + Leucovorin + RO5520985 Fluorouracil Leucovorin RO5520985 0 1
RO5520985 RO5520985 0 1
RO5520985 + Selicrelumab RO5520985 Selicrelumab 0 1

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