Drug Detail


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Drug Name Sitravatinib
Trade Name
Synonyms MGCD516
Drug Descriptions

Sitravatinib (MGCD516) inhibits several receptor tyrosine kinases including AXL, MET, KIT, VEGFR1-3, TYRO3, RET family members, TRK family members, DDR, and Eph family members, resulting in abrogation of downstream signaling and decreased cell proliferation in tumors overexpressing the target proteins (PMID: 26675259, PMID: 30501104, PMID: 32525624).

DrugClasses AXL Inhibitor 28 DDR1 Inhibitor 8 DDR2 inhibitor 7 KIT Inhibitor 53 MERTK Inhibitor 13 MET Inhibitor 55 RET Inhibitor 45 Trk Receptor Inhibitor (Pan) 29 TYRO3 Inhibitor 8 VEGFR Inhibitor (Pan) 33
CAS Registry Number 1123837-84-2
NCIT ID C117734


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Enfortumab vedotin-ejfv + Sitravatinib Enfortumab vedotin-ejfv Sitravatinib 0 1
Ipilimumab + Nivolumab + Sitravatinib Ipilimumab Nivolumab Sitravatinib 0 1
Ipilimumab + Sitravatinib Ipilimumab Sitravatinib 0 1
Nivolumab + Sitravatinib Nivolumab Sitravatinib 0 8
Pembrolizumab + Sitravatinib Pembrolizumab Sitravatinib 0 3
Sitravatinib Sitravatinib 0 4
Sitravatinib + Tislelizumab Sitravatinib Tislelizumab 0 1

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