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Drug Name MGCD516
Trade Name
Synonyms Sitravatinib
Drug Descriptions

MGCD516 (Sitravatinib) inhibits several receptor tyrosine kinases including AXL, MET, KIT, VEGFR1-3, TYRO3, RET family members, TRK family members, DDR, and Eph family members, resulting in abrogation of downstream signaling and decreased cell proliferation in tumors overexpressing the target proteins (PMID: 26675259, PMID: 30501104, PMID: 32525624).

DrugClasses AXL Inhibitor 29 DDR1 Inhibitor 8 DDR2 inhibitor 7 KIT Inhibitor 51 MERTK Inhibitor 11 MET Inhibitor 53 RET Inhibitor 39 Trk Receptor Inhibitor (Pan) 24 TYRO3 Inhibitor 8 VEGFR Inhibitor (Pan) 32
CAS Registry Number 1123837-84-2
NCIT ID C117734

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ipilimumab + MGCD516 + Nivolumab Ipilimumab MGCD516 Nivolumab 0 1
MGCD516 MGCD516 8 2
MGCD516 + Nivolumab MGCD516 Nivolumab 0 6


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