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Drug Name ONC201
Trade Name
Synonyms TIC-10|TIC10
Drug Descriptions

ONC201 (TIC-10) binds to the G-protein coupled receptor, DRD2, leading to inactivation of AKT and ERK, which relocates Foxo3a to the nucleus and then leads to tumor cell apoptosis mediated by (TNF)-related apoptosis-inducing ligand (TRAIL) signaling (PMID: 23390247) and targets the mitochondrial protease, ClpP (PMID: 31021596).

DrugClasses Akt Inhibitor (Pan) 18 ERK Inhibitor (pan) 15

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + ONC201 Bevacizumab ONC201 0 0
Dexamethasone + Ixazomib + ONC201 Dexamethasone Ixazomib ONC201 0 1
Docetaxel + ONC201 Docetaxel ONC201 1 0
Ibrutinib + ONC201 Ibrutinib ONC201 1 0
Navitoclax + ONC201 Navitoclax ONC201 0 0
Nivolumab + ONC201 Nivolumab ONC201 0 1
ONC201 ONC201 12 17
ONC201 + Paclitaxel ONC201 Paclitaxel 1 1
ONC201 + Venetoclax ONC201 Venetoclax 2 0


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