Drug Detail


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Drug Name XAV939
Trade Name
Synonyms XAV-939
Drug Descriptions

XAV939 selectively inhibits Wnt/beta-catenin-mediated signaling by inhibiting tankyrase1/2, thus stabilizing axin and stimulating beta-catenin degradation (PMID: 19759537, PMID: 32681294).

DrugClasses Tankyrase Inhibitor 11
CAS Registry Number 284028-89-3


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Everolimus + XAV939 Everolimus XAV939 0 0
Imatinib + XAV939 Imatinib XAV939 1 0
Palbociclib + XAV939 Palbociclib XAV939 0 0
unspecified PD-1 antibody + XAV939 XAV939 unspecified PD-1 antibody 0 0
Vandetanib + XAV939 Vandetanib XAV939 0 0
XAV939 XAV939 8 0

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