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EPZ004777 is a small molecule that inhibits DOT1L, which results in decreased histone H3 lysine 79 dimethylation, and potentially leads to decreased tumor cell proliferation (PMID: 21741596, PMID: 27535106, PMID: 31888761).
|DrugClasses||DOT1L Inhibitor 3|
|CAS Registry Number||1338466-77-5|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|