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Drug Name Tagraxofusp-erzs
Trade Name Elzonris
Synonyms Tagraxofusp|SL-401|DT3881L3|DT-3881L3
Drug Descriptions

Elzonris (Tagraxofusp-erzs) is a fusion protein consists of human interleukin 3 (IL3) and the first 388 amino acids of diphtheria toxin [DT(388)], which binds to IL3 receptors and subsequently inhibits protein synthesis, leading to cell death (PMID: 28479592). Elzonris (tagraxofusp-erzs) is FDA approved for use in pediatric and adult patients with blastic plasmacytoid dendritic cell neoplasm (FDA.gov).

DrugClasses
CAS Registry Number 2055491-00-2
NCIT ID C64769

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Cytarabine + Hydrocortisone + Methotrexate + Tagraxofusp-erzs Azacitidine Cytarabine Hydrocortisone Methotrexate Tagraxofusp-erzs 0 1
Azacitidine + Tagraxofusp-erzs Azacitidine Tagraxofusp-erzs 0 2
Azacitidine + Tagraxofusp-erzs + Venetoclax Azacitidine Tagraxofusp-erzs Venetoclax 0 2
Cyclophosphamide + Dexamethasone + Mesna + Methotrexate + Rituximab + Tagraxofusp-erzs + Vincristine Sulfate Cyclophosphamide Dexamethasone Mesna Methotrexate Rituximab Tagraxofusp-erzs Vincristine Sulfate 0 1
Cytarabine + Dexamethasone + Hydrocortisone + Methotrexate + Tagraxofusp-erzs + Vincristine Sulfate Cytarabine Dexamethasone Hydrocortisone Methotrexate Tagraxofusp-erzs Vincristine Sulfate 0 1
Cytarabine + Filgrastim + Methotrexate + Rituximab + Tagraxofusp-erzs Cytarabine Filgrastim Methotrexate Rituximab Tagraxofusp-erzs 0 1
Cytarabine + Fludarabine + Hydrocortisone + Methotrexate + Tagraxofusp-erzs Cytarabine Fludarabine Hydrocortisone Methotrexate Tagraxofusp-erzs 0 1
Cytarabine + Hydrocortisone + Methotrexate + Tagraxofusp-erzs Cytarabine Hydrocortisone Methotrexate Tagraxofusp-erzs 0 1
Mercaptopurine + Methotrexate + Prednisone + Tagraxofusp-erzs + Venetoclax + Vincristine Sulfate Mercaptopurine Methotrexate Prednisone Tagraxofusp-erzs Venetoclax Vincristine Sulfate 0 1
Tagraxofusp-erzs Tagraxofusp-erzs 0 5
Tagraxofusp-erzs + Venetoclax Tagraxofusp-erzs Venetoclax 0 1


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