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Drug Name RO5126766
Trade Name
Synonyms VS-6766|CH5126766
Drug Descriptions

RO5126766 (VS-6766) is dual RAF-MEK1/2 inhibitor with effectiveness against both BRAF and RAS mutated cells (PMID: 25422890).

DrugClasses MEK inhibitor (Pan) 22 MEK1 Inhibitor 20 MEK2 Inhibitor 18 RAF Inhibitor (Pan) 20
CAS Registry Number 946128-88-7
NCIT ID C80060

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cetuximab + RO5126766 Cetuximab RO5126766 0 1
Defactinib + RO5126766 Defactinib RO5126766 0 4
Everolimus + RO5126766 Everolimus RO5126766 0 1
RO5126766 RO5126766 13 4
RO5126766 + Sotorasib RO5126766 Sotorasib 0 1
RO5126766 + VS-4718 RO5126766 VS-4718 0 0


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