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Drug Name RO5126766
Trade Name
Synonyms Avutometinib|VS-6766|VS6766|VS 6766|CH5126766|CH-5126766|R-7304|RG-7304
Drug Descriptions

RO5126766 (VS-6766) is a RAF/MEK inhibitor, which potentially leads to decreased tumor cell growth and inhibition of tumor growth (PMID: 34288272).

DrugClasses MEK inhibitor (Pan) 26 MEK1 Inhibitor 26 MEK2 Inhibitor 24 RAF Inhibitor (Pan) 28
CAS Registry Number 946128-88-7
NCIT ID C80060

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Fulvestrant + RO5126766 Abemaciclib Fulvestrant RO5126766 0 1
Adagrasib + RO5126766 Adagrasib RO5126766 0 1
Afatinib + RO5126766 Afatinib RO5126766 0 0
Cetuximab + Defactinib + RO5126766 Cetuximab Defactinib RO5126766 0 1
Cetuximab + RO5126766 Cetuximab RO5126766 0 1
Defactinib + Encorafenib + RO5126766 Defactinib Encorafenib RO5126766 0 1
Defactinib + Gemcitabine + Nab-paclitaxel + RO5126766 Defactinib Gemcitabine Nab-paclitaxel RO5126766 0 1
Defactinib + Letrozole + RO5126766 Defactinib Letrozole RO5126766 0 1
Defactinib + RO5126766 Defactinib RO5126766 0 9
Defactinib + RO5126766 + Sotorasib Defactinib RO5126766 Sotorasib 0 1
Eribulin + RO5126766 Eribulin RO5126766 0 0
Everolimus + RO5126766 Everolimus RO5126766 1 1
MRTX0902 + RO5126766 MRTX0902 RO5126766 0 0
Panitumumab + RO5126766 Panitumumab RO5126766 0 0
RO5126766 RO5126766 15 6
RO5126766 + Sotorasib RO5126766 Sotorasib 0 1
RO5126766 + VS-4718 RO5126766 VS-4718 0 0


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