Drug Detail


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Drug Name GDC-0084
Trade Name
Synonyms GDC0084|Paxalisib
Drug Descriptions

Paxalisib (GDC-0084) is a dual pan-PI3K and mTOR inhibitor, which prevents cell proliferation and potentially inhibits tumor growth (PMID: 22619466, PMID: 32269051, PMID: 31937616).

DrugClasses mTOR Inhibitor 51 PI3K Inhibitor (Pan) 40
CAS Registry Number 1382979-44-3
NCIT ID C116877


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Therapy Name Drugs Efficacy Evidence Clinical Trials
GDC-0084 GDC-0084 1 6
GDC-0084 + Irinotecan + Temozolomide GDC-0084 Irinotecan Temozolomide 0 1
GDC-0084 + Metformin GDC-0084 Metformin 0 1
GDC-0084 + ONC201 GDC-0084 ONC201 0 1
GDC-0084 + Trastuzumab GDC-0084 Trastuzumab 0 1

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