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Drug Name Birabresib
Trade Name
Synonyms Y-803|MK-8628|OTX015|OTX-015
Drug Descriptions

Birabresib (OTX015) is an inhibitor of the BET bromodomain proteins BRD3, BRD4, and BRD5, which inhibits interaction with acetylated histone H4, potentially resulting in decreased tumor cell proliferation (Mol Cancer Ther Nov 2013 12:C244, PMID: 29733771, PMID: 31204545).

DrugClasses BET Inhibitor (Pan) 32
CAS Registry Number 202590-98-5
NCIT ID C103298


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Birabresib Birabresib 3 3
Birabresib + Bortezomib Birabresib Bortezomib 0 0
Birabresib + Carfilzomib Birabresib Carfilzomib 0 0
Birabresib + Crizotinib Birabresib Crizotinib 0 0
Birabresib + GSK2801 Birabresib GSK2801 0 0
Birabresib + Osimertinib Birabresib Osimertinib 0 0
Birabresib + Rucaparib Birabresib Rucaparib 0 0
Birabresib + Ziftomenib Birabresib Ziftomenib 0 0

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