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S-49076 is a multi-kinase inhibitor that inhibits wild-type and mutant forms of MET and FGFR1/2, as well as FGFR3, AXL, and MER, resulting in decreased downstream signaling, and potentially resulting in decreased tumor growth (PMID: 23804704).
|DrugClasses||AXL Inhibitor 27 FGFR1 Inhibitor 23 FGFR2 Inhibitor 15 FGFR3 Inhibitor 13 MET Inhibitor 52|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Bevacizumab + S-49076||Bevacizumab S-49076||1||0|