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S-49076 is a multi-kinase inhibitor that inhibits wild-type and mutant forms of MET and FGFR1-2, as well as FGFR3, AXL, MER, and AURKB, resulting in decreased downstream signaling, and potentially resulting in decreased tumor growth (PMID: 23804704, PMID: 28624695, PMID: 28619752).
|DrugClasses||Aurkb Inhibitors 20 AXL Inhibitor 29 FGFR1 Inhibitor 23 FGFR2 Inhibitor 17 FGFR3 Inhibitor 12 MET Inhibitor 54|
|CAS Registry Number||1265965-22-7|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Bevacizumab + S-49076||Bevacizumab S-49076||0||0|