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JW55 selectively inhibits Wnt/beta-catenin-mediated signaling by inhibiting tankyrase1/2, thus stabilizing axin and stimulating beta-catenin degradation, which prevents cell division and decreases tumor growth (PMID: 22440753).
|DrugClasses||Tankyrase Inhibitor 11|
|CAS Registry Number||664993-53-7|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|