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Drug Name Poly ICLC
Trade Name
Synonyms Hiltonol
Drug Descriptions

Hiltonol (poly ICLC) is a synthetic double stranded RNA complex, which induces interferon production and stimulates anti-tumor immune response (PMID: 22126373).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
6MHP vaccine + Montanide ISA 51 + Poly ICLC 6MHP vaccine Montanide ISA 51 Poly ICLC 0 1
6MHP vaccine + Montanide ISA 51 + Poly ICLC + Varlilumab 6MHP vaccine Montanide ISA 51 Poly ICLC Varlilumab 0 1
APX005M + NEO-PV-01 + Nivolumab + Poly ICLC APX005M NEO-PV-01 Nivolumab Poly ICLC 0 1
Atezolizumab + Poly ICLC Atezolizumab Poly ICLC 0 1
Carboplatin + NEO-PV-01 + Pembrolizumab + Pemetrexed Disodium + Poly ICLC Carboplatin NEO-PV-01 Pembrolizumab Pemetrexed Disodium Poly ICLC 0 1
CDX-301 + Nivolumab + Poly ICLC CDX-301 Nivolumab Poly ICLC 0 1
CDX-301 + Pembrolizumab + Poly ICLC CDX-301 Pembrolizumab Poly ICLC 0 1
CDX-301 + Poly ICLC CDX-301 Poly ICLC 0 1
Cemiplimab + Poly ICLC Cemiplimab Poly ICLC 0 1
Cyclophosphamide + Poly ICLC + Sargramostim Cyclophosphamide Poly ICLC Sargramostim 0 1
DC tumor cell lysate vaccine + Pembrolizumab + Poly ICLC DC tumor cell lysate vaccine Pembrolizumab Poly ICLC 0 1
DC tumor cell lysate vaccine + Poly ICLC DC tumor cell lysate vaccine Poly ICLC 0 1
Decitabine + Nivolumab + Poly ICLC + Rasdegafusp alfa Decitabine Nivolumab Poly ICLC Rasdegafusp alfa 0 1
DNAJB1-PRKACA peptide vaccine + Ipilimumab + Nivolumab + Poly ICLC DNAJB1-PRKACA peptide vaccine Ipilimumab Nivolumab Poly ICLC 0 1
Durvalumab + Poly ICLC Durvalumab Poly ICLC 0 2
Durvalumab + Poly ICLC + PVX-410 Durvalumab PVX-410 Poly ICLC 0 1
GBM6-AD lysate protein vaccine + Poly ICLC GBM6-AD lysate protein vaccine Poly ICLC 0 1
H3.3K27M peptide vaccine + Montanide ISA 51 + Nivolumab + Poly ICLC + Tetanus Toxoid peptide H3.3K27M peptide vaccine Montanide ISA 51 Nivolumab Poly ICLC Tetanus Toxoid peptide 0 1
H3.3K27M peptide vaccine + Montanide ISA 51 + Poly ICLC + Tetanus Toxoid peptide H3.3K27M peptide vaccine Montanide ISA 51 Poly ICLC Tetanus Toxoid peptide 0 1
H3.3K27M peptide vaccine + Poly ICLC H3.3K27M peptide vaccine Poly ICLC 0 0
IMA950 + Poly ICLC IMA950 Poly ICLC 0 1
Ipilimumab + NEO-PV-01 + Nivolumab + Poly ICLC Ipilimumab NEO-PV-01 Nivolumab Poly ICLC 0 1
Ipilimumab + Nivolumab + Poly ICLC Ipilimumab Nivolumab Poly ICLC 0 1
NEO-PV-01 + Nivolumab + Poly ICLC NEO-PV-01 Nivolumab Poly ICLC 0 1
NEO-PV-01 + Poly ICLC NEO-PV-01 Poly ICLC 0 1
Neoantigen peptide vaccine + Poly ICLC Neoantigen peptide vaccine Poly ICLC 0 1
NeoVax + Poly ICLC NeoVax Poly ICLC 0 0
Nivolumab + Poly ICLC Nivolumab Poly ICLC 0 2
Nivolumab + Poly ICLC + Rituximab Nivolumab Poly ICLC Rituximab 0 1
Oregovomab + Poly ICLC Oregovomab Poly ICLC 0 1
PANDA-VAC + Pembrolizumab + Poly ICLC PANDA-VAC Pembrolizumab Poly ICLC 0 1
PANDA-VAC + Poly ICLC PANDA-VAC Poly ICLC 0 0
Pembrolizumab + Poly ICLC Pembrolizumab Poly ICLC 0 2
Poly ICLC Poly ICLC 0 18


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