Drug Detail


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Drug Name Tirabrutinib
Trade Name
Synonyms ONO-GS-4059|ONO-WG-307|ONO-4059
Drug Descriptions

Tirabrutinib (ONO-4059) inhibits Bruton's Tyrosine Kinase (BTK), which leads to decreased B-cell proliferation and differentiation, and may have antitumor activity in B-cell malignancies (PMID: 23958373, PMID: 27776353, PMID: 32156743).

DrugClasses BTK inhibitor 35
CAS Registry Number 1351636-18-4
NCIT ID C102876


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Entospletinib + Obinutuzumab + Tirabrutinib Entospletinib Obinutuzumab Tirabrutinib 0 1
Entospletinib + Tirabrutinib Entospletinib Tirabrutinib 0 1
Idelalisib + Obinutuzumab + Tirabrutinib Idelalisib Obinutuzumab Tirabrutinib 0 1
Idelalisib + Tirabrutinib Idelalisib Tirabrutinib 0 1
Tirabrutinib Tirabrutinib 0 2

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