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MOXR0916 is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response (PMID: 25763356).
|DrugClasses||OX40 Antibody 10|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Atezolizumab + MOXR0916||Atezolizumab MOXR0916||0||1|