Drug Detail


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Drug Name BKT140
Trade Name
Synonyms TN14003|BL-8040|BL8040|Motixafortide
Drug Descriptions

BL-8040 (BKT140) is a selective CXCR4 antagonist that prevents SDF-1 (CXCL12) binding, which may lead to decreased tumor growth (PMID: 21138752).

DrugClasses CXCR4 Inhibitor 15
CAS Registry Number 664334-36-5
NCIT ID C88309


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Therapy Name Drugs Efficacy Evidence Clinical Trials
anti-thymocyte globulin + BKT140 + Cyclosporine + Methylprednisolone BKT140 Cyclosporine Methylprednisolone anti-thymocyte globulin 0 1
Atezolizumab + BKT140 Atezolizumab BKT140 0 3
BKT140 BKT140 0 2
BKT140 + Cemiplimab + Gemcitabine + Nab-paclitaxel BKT140 Cemiplimab Gemcitabine Nab-paclitaxel 0 1
BKT140 + Cytarabine BKT140 Cytarabine 0 1
BKT140 + Filgrastim BKT140 Filgrastim 0 1
BKT140 + Fluorouracil + Leucovorin + MM-398 + Pembrolizumab BKT140 Fluorouracil Leucovorin MM-398 Pembrolizumab 0 0
BKT140 + Gemcitabine + Nab-paclitaxel BKT140 Gemcitabine Nab-paclitaxel 0 0
BKT140 + Nelarabine BKT140 Nelarabine 0 1
BKT140 + Pembrolizumab BKT140 Pembrolizumab 0 2

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