Drug Detail


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Drug Name Abivertinib
Trade Name
Synonyms Avitinib|AC0010|AC0010MA
Drug Descriptions

Abivertinib (AC0010) is a BTK inhibitor and a third-generation EGFR inhibitor that blocks the activity of mutant forms of EGFR while sparing wild-type EGFR, which potentially results in increased apoptosis and cell cycle arrest, and decreased viability and colony formation, and inhibits tumor growth (PMID: 27573423, PMID: 31310800).

DrugClasses BTK inhibitor 36 EGFR Inhibitor 3rd gen 26
CAS Registry Number 1557267-42-1
NCIT ID C147125


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Abivertinib Abiraterone Abivertinib 0 1
Abivertinib Abivertinib 1 1
Abivertinib + Omacetaxine mepesuccinate Abivertinib Omacetaxine mepesuccinate 1 0

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