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Drug Name thioureidobutyronitrile
Trade Name
Synonyms Kevetrin|NSC-525990
Drug Descriptions

Kevetrin (thioureidobutyronitrile) leads to stabilization of wild-type Tp53 and degradation of mutant Tp53, resulting in apoptosis and decreased growth of tumors with wild-type and mutant Tp53 (J Clin Oncol 31, 2013 (suppl; abstr TPS2627)).

DrugClasses p53 Activator 11
CAS Registry Number 500863-50-3
NCIT ID C102881

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Therapy Name Drugs Efficacy Evidence Clinical Trials
thioureidobutyronitrile thioureidobutyronitrile 6 2


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