Drug Detail


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Drug Name sEphB4-HSA
Trade Name
Drug Descriptions

sEphB4-HSA is a fusion protein that consists of the extracellular domain of human ephrin type-B receptor 4 (EphB4) and human serum albumin (HSA), which acts as a decoy to inhibit EphB4 signaling, leading to inhibition of tumor cell growth (PMID: 23721559, PMID: 25148033, PMID: 27941840).

DrugClasses EPHB4 Inhibitor 6
CAS Registry Number NA
NCIT ID C102569


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + sEphB4-HSA Bevacizumab sEphB4-HSA 0 0
Cetuximab + sEphB4-HSA Cetuximab sEphB4-HSA 0 1
Cytarabine + sEphB4-HSA Cytarabine sEphB4-HSA 0 1
Paclitaxel + sEphB4-HSA Paclitaxel sEphB4-HSA 0 0
Pembrolizumab + sEphB4-HSA Pembrolizumab sEphB4-HSA 0 3
sEphB4-HSA sEphB4-HSA 0 3
sEphB4-HSA + Vincristine sulfate liposome Vincristine sulfate liposome sEphB4-HSA 0 1

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