Drug Detail


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Drug Name Parsaclisib
Trade Name
Synonyms INCB050465|INCB 50465|INCB-50465|INCB50465|WHO 10589
Drug Descriptions

Parsaclisib (INCB050465) inhibits PI3K-delta, blocking activation of AKT signaling pathway and leading to apoptosis of PIK3CD expressing tumor cells (PMID: 31749910).

DrugClasses PIK3CD inhibitor 26
CAS Registry Number 1426698-88-5
NCIT ID C113434


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Obinutuzumab + Parsaclisib Bendamustine Obinutuzumab Parsaclisib 0 1
Bendamustine + Parsaclisib + Rituximab Bendamustine Parsaclisib Rituximab 0 1
Cyclophosphamide + Doxorubicin + Parsaclisib + Pegfilgrastim + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Parsaclisib Pegfilgrastim Prednisone Rituximab Vincristine Sulfate 0 1
Ibrutinib + Parsaclisib Ibrutinib Parsaclisib 0 1
INCB053914 + Parsaclisib INCB053914 Parsaclisib 0 1
Itacitinib + Parsaclisib Itacitinib Parsaclisib 0 3
Parsaclisib Parsaclisib 0 6
Parsaclisib + Pembrolizumab Parsaclisib Pembrolizumab 0 1
Parsaclisib + Retifanlimab Parsaclisib Retifanlimab 0 1
Parsaclisib + Rituximab Parsaclisib Rituximab 0 1
Parsaclisib + Romidepsin Parsaclisib Romidepsin 0 1
Parsaclisib + Ruxolitinib Parsaclisib Ruxolitinib 0 3
Parsaclisib + Tafasitamab-cxix Parsaclisib Tafasitamab-cxix 0 1

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