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Drug Name Parsaclisib
Trade Name
Synonyms INCB050465
Drug Descriptions

Parsaclisib (INCB050465) inhibits PI3K-delta, blocking activation of AKT signaling pathway and leading to apoptosis of PIK3CD expressing tumor cells (PMID: 31749910).

DrugClasses PIK3CD inhibitor 25

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Obinutuzumab + Parsaclisib Bendamustine Obinutuzumab Parsaclisib 0 1
Bendamustine + Parsaclisib + Rituximab Bendamustine Parsaclisib Rituximab 0 1
Cyclophosphamide + Doxorubicin + Parsaclisib + Pegfilgrastim + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Parsaclisib Pegfilgrastim Prednisone Rituximab Vincristine Sulfate 0 1
Ibrutinib + Parsaclisib Ibrutinib Parsaclisib 0 1
INCB053914 + Parsaclisib INCB053914 Parsaclisib 0 1
Itacitinib + Parsaclisib Itacitinib Parsaclisib 1 2
Parsaclisib Parsaclisib 6 5
Parsaclisib + Pembrolizumab Parsaclisib Pembrolizumab 0 1
Parsaclisib + Retifanlimab Parsaclisib Retifanlimab 0 1
Parsaclisib + Rituximab Parsaclisib Rituximab 0 1
Parsaclisib + Ruxolitinib Parsaclisib Ruxolitinib 0 1


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