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Drug Name Inotuzumab ozogamicin
Trade Name Besponsa
Synonyms CMC-544|InO
Drug Descriptions

Besponsa (inotuzumab ozogamicin) consists of calecheamicin covalently linked to anti-CD22 antibody, which delivers calecheamicin into CD22-positive cells, leading to DNA damage and apoptosis (PMID: 24389139). Besponsa (inotuzumab ozogamicin) is FDA approved for relapsed or refractory B-cell precursor acute lymphoblastic leukemia (FDA.gov).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Fludarabine + Inotuzumab ozogamicin Bendamustine Fludarabine Inotuzumab ozogamicin 0 1
Bendamustine + Fludarabine + Inotuzumab ozogamicin + Tacrolimus Bendamustine Fludarabine Inotuzumab ozogamicin Tacrolimus 0 1
Blinatumomab + Inotuzumab ozogamicin Blinatumomab Inotuzumab ozogamicin 0 1
Bosutinib + Inotuzumab ozogamicin Bosutinib Inotuzumab ozogamicin 0 1
Cyclophosphamide + Cytarabine + Inotuzumab ozogamicin + Methotrexate + Vincristine Sulfate Cyclophosphamide Cytarabine Inotuzumab ozogamicin Methotrexate Vincristine Sulfate 0 1
Cyclophosphamide + Doxorubicin + Etoposide + Inotuzumab ozogamicin + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Etoposide Inotuzumab ozogamicin Prednisone Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Doxorubicin + Etoposide + Inotuzumab ozogamicin + Prednisone + Vincristine Sulfate Cyclophosphamide Doxorubicin Etoposide Inotuzumab ozogamicin Prednisone Vincristine Sulfate 0 1
Cyclophosphamide + Inotuzumab ozogamicin + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Inotuzumab ozogamicin Prednisone Rituximab Vincristine Sulfate 1 0
Cytarabine + Daunorubicin + Inotuzumab ozogamicin + Methotrexate + Pegaspargase + Prednisone + Vincristine Sulfate Cytarabine Daunorubicin Inotuzumab ozogamicin Methotrexate Pegaspargase Prednisone Vincristine Sulfate 0 0
Cytarabine + Daunorubicin + Inotuzumab ozogamicin + Methotrexate + Prednisone + Vincristine Sulfate Cytarabine Daunorubicin Inotuzumab ozogamicin Methotrexate Prednisone Vincristine Sulfate 0 0
Cytarabine + Inotuzumab ozogamicin + Methotrexate Cytarabine Inotuzumab ozogamicin Methotrexate 0 1
Daunorubicin + Inotuzumab ozogamicin + Pegaspargase + Prednisone + Vincristine Sulfate Daunorubicin Inotuzumab ozogamicin Pegaspargase Prednisone Vincristine Sulfate 0 1
Daunorubicin + Inotuzumab ozogamicin + Prednisone + Vincristine Sulfate Daunorubicin Inotuzumab ozogamicin Prednisone Vincristine Sulfate 0 1
Fludarabine + Inotuzumab ozogamicin + Melphalan + Tacrolimus Fludarabine Inotuzumab ozogamicin Melphalan Tacrolimus 0 1
Inotuzumab ozogamicin Inotuzumab ozogamicin 1 12
Inotuzumab ozogamicin + Methotrexate Inotuzumab ozogamicin Methotrexate 0 1
Inotuzumab ozogamicin + Vincristine sulfate liposome Inotuzumab ozogamicin Vincristine sulfate liposome 0 1


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