Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Inotuzumab ozogamicin
Trade Name Besponsa
Synonyms CMC-544|InO
Drug Descriptions

Besponsa (inotuzumab ozogamicin) consists of calecheamicin covalently linked to anti-CD22 antibody, which delivers calecheamicin into CD22-positive cells, potentially leading to DNA damage and apoptosis (PMID: 24389139). Besponsa (inotuzumab ozogamicin) is FDA-approved for use in adult and pediatric patients 1 year and older with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia (FDA.gov).

DrugClasses CD22 Immune Cell Therapy 16
CAS Registry Number 635715-01-4
NCIT ID C71542

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Fludarabine + Inotuzumab ozogamicin Bendamustine Fludarabine Inotuzumab ozogamicin 0 1
Bendamustine + Fludarabine + Inotuzumab ozogamicin + Tacrolimus Bendamustine Fludarabine Inotuzumab ozogamicin Tacrolimus 0 1
Blinatumomab + Cyclophosphamide + Cytarabine + Dexamethasone + Inotuzumab ozogamicin + Mercaptopurine + Methotrexate + Pegfilgrastim + Prednisone + Rituximab + Vincristine Sulfate Blinatumomab Cyclophosphamide Cytarabine Dexamethasone Inotuzumab ozogamicin Mercaptopurine Methotrexate Pegfilgrastim Prednisone Rituximab Vincristine Sulfate 0 1
Blinatumomab + Cyclophosphamide + Dexamethasone + Doxorubicin + Inotuzumab ozogamicin + Vincristine Sulfate Blinatumomab Cyclophosphamide Dexamethasone Doxorubicin Inotuzumab ozogamicin Vincristine Sulfate 0 0
Blinatumomab + Cyclophosphamide + Dexamethasone + Inotuzumab ozogamicin + Vincristine Sulfate Blinatumomab Cyclophosphamide Dexamethasone Inotuzumab ozogamicin Vincristine Sulfate 0 1
Blinatumomab + Inotuzumab ozogamicin Blinatumomab Inotuzumab ozogamicin 0 2
Bosutinib + Inotuzumab ozogamicin Bosutinib Inotuzumab ozogamicin 0 1
Cyclophosphamide + Cytarabine + Inotuzumab ozogamicin + Methotrexate + Vincristine Sulfate Cyclophosphamide Cytarabine Inotuzumab ozogamicin Methotrexate Vincristine Sulfate 0 1
Cyclophosphamide + Dexamethasone + Inotuzumab ozogamicin + Mesna + Rituximab + Vincristine Sulfate Cyclophosphamide Dexamethasone Inotuzumab ozogamicin Mesna Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Dexamethasone + Inotuzumab ozogamicin + Mesna + Vincristine Sulfate Cyclophosphamide Dexamethasone Inotuzumab ozogamicin Mesna Vincristine Sulfate 0 1
Cyclophosphamide + Doxorubicin + Etoposide + Inotuzumab ozogamicin + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Etoposide Inotuzumab ozogamicin Prednisone Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Doxorubicin + Etoposide + Inotuzumab ozogamicin + Prednisone + Vincristine Sulfate Cyclophosphamide Doxorubicin Etoposide Inotuzumab ozogamicin Prednisone Vincristine Sulfate 0 1
Cyclophosphamide + Inotuzumab ozogamicin + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Inotuzumab ozogamicin Prednisone Rituximab Vincristine Sulfate 0 0
Cytarabine + Daunorubicin + Inotuzumab ozogamicin + Methotrexate + Pegaspargase + Prednisone + Vincristine Sulfate Cytarabine Daunorubicin Inotuzumab ozogamicin Methotrexate Pegaspargase Prednisone Vincristine Sulfate 0 0
Cytarabine + Daunorubicin + Inotuzumab ozogamicin + Methotrexate + Prednisone + Vincristine Sulfate Cytarabine Daunorubicin Inotuzumab ozogamicin Methotrexate Prednisone Vincristine Sulfate 0 0
Cytarabine + Inotuzumab ozogamicin + Methotrexate Cytarabine Inotuzumab ozogamicin Methotrexate 0 1
Cytarabine + Inotuzumab ozogamicin + Methotrexate + Methylprednisolone Cytarabine Inotuzumab ozogamicin Methotrexate Methylprednisolone 0 1
Cytarabine + Inotuzumab ozogamicin + Methotrexate + Methylprednisolone + Rituximab Cytarabine Inotuzumab ozogamicin Methotrexate Methylprednisolone Rituximab 0 1
Dasatinib + Dexamethasone + Inotuzumab ozogamicin + Methotrexate Dasatinib Dexamethasone Inotuzumab ozogamicin Methotrexate 0 1
Dasatinib + Dexamethasone + Inotuzumab ozogamicin + Methotrexate + Vincristine Sulfate Dasatinib Dexamethasone Inotuzumab ozogamicin Methotrexate Vincristine Sulfate 0 1
Dasatinib + Inotuzumab ozogamicin + Methotrexate Dasatinib Inotuzumab ozogamicin Methotrexate 0 1
Daunorubicin + Inotuzumab ozogamicin + Pegaspargase + Prednisone + Vincristine Sulfate Daunorubicin Inotuzumab ozogamicin Pegaspargase Prednisone Vincristine Sulfate 0 1
Daunorubicin + Inotuzumab ozogamicin + Prednisone + Vincristine Sulfate Daunorubicin Inotuzumab ozogamicin Prednisone Vincristine Sulfate 0 1
Dexamethasone + Inotuzumab ozogamicin + Methotrexate + Ponatinib + Vincristine Sulfate Dexamethasone Inotuzumab ozogamicin Methotrexate Ponatinib Vincristine Sulfate 0 1
Dexamethasone + Inotuzumab ozogamicin + Venetoclax Dexamethasone Inotuzumab ozogamicin Venetoclax 0 1
Fludarabine + Inotuzumab ozogamicin + Melphalan + Tacrolimus Fludarabine Inotuzumab ozogamicin Melphalan Tacrolimus 0 1
Imatinib + Inotuzumab ozogamicin Imatinib Inotuzumab ozogamicin 0 0
Inotuzumab ozogamicin Inotuzumab ozogamicin 0 15
Inotuzumab ozogamicin + Methotrexate Inotuzumab ozogamicin Methotrexate 0 1
Inotuzumab ozogamicin + Ponatinib Inotuzumab ozogamicin Ponatinib 0 0
Inotuzumab ozogamicin + Venetoclax Inotuzumab ozogamicin Venetoclax 0 0
Inotuzumab ozogamicin + Vincristine sulfate liposome Inotuzumab ozogamicin Vincristine sulfate liposome 0 1


Additional content available in CKB BOOST