Drug Detail

Drug Name inotuzumab ozogamicin
Trade Name Besponsa
Synonyms CMC-544|InO
Drug Descriptions

Besponsa (inotuzumab ozogamicin) consists of calecheamicin covalently linked to anti-CD22 antibody, which delivers calecheamicin into CD22-positive cells, leading to DNA damage and apoptosis (PMID: 24389139). Besponsa (inotuzumab ozogamicin) is FDA approved for relapsed or refractory B-cell precursor acute lymphoblastic leukemia (FDA.gov).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Fludarabine + inotuzumab ozogamicin Bendamustine Fludarabine inotuzumab ozogamicin 0 1
Bendamustine + Fludarabine + inotuzumab ozogamicin + Tacrolimus Bendamustine Fludarabine Tacrolimus inotuzumab ozogamicin 0 1
Blinatumomab + inotuzumab ozogamicin Blinatumomab inotuzumab ozogamicin 0 1
Bosutinib + inotuzumab ozogamicin Bosutinib inotuzumab ozogamicin 0 1
Cyclophosphamide + Cytarabine + inotuzumab ozogamicin + Methotrexate + Vincristine Cyclophosphamide Cytarabine Methotrexate Vincristine inotuzumab ozogamicin 0 1
Cyclophosphamide + Doxorubicin + Etoposide + inotuzumab ozogamicin + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Etoposide Prednisone Rituximab Vincristine inotuzumab ozogamicin 0 1
Cyclophosphamide + Doxorubicin + Etoposide + inotuzumab ozogamicin + Prednisone + Vincristine Cyclophosphamide Doxorubicin Etoposide Prednisone Vincristine inotuzumab ozogamicin 0 1
Cyclophosphamide + inotuzumab ozogamicin + Prednisone + Rituximab + Vincristine Cyclophosphamide Prednisone Rituximab Vincristine inotuzumab ozogamicin 1 0
Cytarabine + Daunorubicin + inotuzumab ozogamicin + Methotrexate + Pegaspargase + Prednisone + Vincristine Cytarabine Daunorubicin Methotrexate Pegaspargase Prednisone Vincristine inotuzumab ozogamicin 0 0
Cytarabine + Daunorubicin + inotuzumab ozogamicin + Methotrexate + Prednisone + Vincristine Cytarabine Daunorubicin Methotrexate Prednisone Vincristine inotuzumab ozogamicin 0 0
Cytarabine + inotuzumab ozogamicin + Methotrexate Cytarabine Methotrexate inotuzumab ozogamicin 0 1
Daunorubicin + inotuzumab ozogamicin + Pegaspargase + Prednisone + Vincristine Daunorubicin Pegaspargase Prednisone Vincristine inotuzumab ozogamicin 0 1
Daunorubicin + inotuzumab ozogamicin + Prednisone + Vincristine Daunorubicin Prednisone Vincristine inotuzumab ozogamicin 0 1
Fludarabine + inotuzumab ozogamicin + Melphalan + Tacrolimus Fludarabine Melphalan Tacrolimus inotuzumab ozogamicin 0 1
inotuzumab ozogamicin inotuzumab ozogamicin 1 10
inotuzumab ozogamicin + Vincristine sulfate liposome Vincristine sulfate liposome inotuzumab ozogamicin 0 1


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