Drug Detail


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Drug Name A-1210477
Trade Name
Synonyms AOB5551
Drug Descriptions

A-1210477 binds to and inhibits MCL1, resulting in increased apoptosis of MCL1-dependent tumor cells (PMID: 25590800, PMID: 30647404, PMID: 32486166).

DrugClasses MCL1 Inhibitor 18
CAS Registry Number 1668553-26-1


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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1210477 A-1210477 1 0
A-1210477 + A-1331852 A-1210477 A-1331852 0 0
A-1210477 + Cobimetinib A-1210477 Cobimetinib 0 0
A-1210477 + Cobimetinib + Vemurafenib A-1210477 Cobimetinib Vemurafenib 0 0
A-1210477 + G-TPP A-1210477 G-TPP 0 0
A-1210477 + LAM-003 A-1210477 LAM-003 0 0
A-1210477 + Lapatinib + WEHI-539 A-1210477 Lapatinib WEHI-539 0 0
A-1210477 + Vemurafenib A-1210477 Vemurafenib 0 0
A-1210477 + Venetoclax A-1210477 Venetoclax 1 0
A-1210477 + WEHI-539 A-1210477 WEHI-539 1 0

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