Drug Detail


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Drug Name MK-8353
Trade Name
Synonyms SCH900353
Drug Descriptions

MK-8353 is an analog of SCH772984, which targets both Erk1 and Erk2 and may inhibit cell growth (PMID: 25142146, PMID: 29467321).

DrugClasses ERK Inhibitor (pan) 21
CAS Registry Number 1184173-73-6
NCIT ID C104045


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Lifirafenib + MK-8353 Lifirafenib MK-8353 2 0
MK-8353 MK-8353 2 1
MK-8353 + Pembrolizumab MK-8353 Pembrolizumab 0 1
MK-8353 + Selumetinib MK-8353 Selumetinib 0 1

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