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NSC59984 is a small molecule that both induces degradation of mutant Tp53 and reactivates Tp53 pathway signaling through Tp73, which may result in increased cell death in Tp53-mutant tumor cells (PMID: 26294215, PMID: 30667081).
|DrugClasses||p53 Activator 11|
|CAS Registry Number||803647-40-7|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Cisplatin + NSC59984||Cisplatin NSC59984||1||0|