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NSC319726 restores wild-type conformation to mutant Tp53, resulting in reactivation of Tp53 signaling in Tp53-mutant cells, and potentially leading to increased tumor cell death (PMID: 22624712, PMID: 26719703).
|DrugClasses||p53 Activator 11|
|CAS Registry Number||71555-25-4|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|