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G-631 inhibits Tankyrase 1 and 2 (TNK1, TNK2), resulting in decreased Wnt/Beta-catenin pathway signaling, but has little anti-tumor activity and leads to intestinal toxicity (PMID: 26692561).
|DrugClasses||Tankyrase Inhibitor 11|
|CAS Registry Number||NA|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|